2026-04-29T06:16:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/164252024-09-21T10:39:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc García-Ferreras, Raquel author Osuna-Pérez, Jesús author Ramírez-Santiago, Guillermo author Méndez-Pérez, Almudena author Acosta-Moreno, Andrés M author Del Campo, Lara author Gómez-Sánchez, María J author Iborra, Marta author Herrero-Fernández, Beatriz author González-Granado, José M author Sánchez-Madrid, Francisco author Carrasco, Yolanda R author Boya, Patricia author Martínez-Martín, Nuria author Veiga, Esteban author 2023-07-05 In addition to triggering humoral responses, conventional B cells have been described in vitro to cross-present exogenous antigens activating naïve CD8+ T cells. Nevertheless, the way B cells capture these exogenous antigens and the physiological roles of B cell-mediated cross-presentation remain poorly explored. Here, we show that B cells capture bacteria by trans-phagocytosis from previously infected dendritic cells (DC) when they are in close contact. Bacterial encounter "instructs" the B cells to acquire antigen cross-presentation abilities, in a process that involves autophagy. Bacteria-instructed B cells, henceforth referred to as BacB cells, rapidly degrade phagocytosed bacteria, process bacterial antigens and cross-prime naïve CD8+ T cells which differentiate into specific cytotoxic cells that efficiently control bacterial infections. Moreover, a proof-of-concept experiment shows that BacB cells that have captured bacteria expressing tumor antigens could be useful as novel cellular immunotherapies against cancer. EMBO Rep. 2023 Jul 5;24(7):e56131 http://hdl.handle.net/20.500.12105/16425 37184882 10.15252/embr.202256131 1469-3178 EMBO reports Bacteria-instructed B cells cross-prime naïve CD8+ T cells triggering effective cytotoxic responses.