2026-04-29T04:09:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164062024-09-27T08:50:31Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
García-Culebras, Alicia
author
Cuartero, María Isabel
author
Peña-Martínez, Carolina
author
Moraga, Ana
author
Vázquez-Reyes, Sandra
author
de Castro-Millán, Francisco Javier
author
Cortes-Canteli, Marta
author
Lizasoain, Ignacio
author
Moro, María Ángeles
funder
Ministerio de Ciencia e Innovación (España)
funder
Fondation Leducq
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-09-05T08:35:58Z
2023-09-05T08:35:58Z
2023-06-07
Br J Pharmacol. 2023 Jun 7.
http://hdl.handle.net/20.500.12105/16406
37282844
10.1111/bph.16159
1476-5381
British journal of pharmacology
Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post-stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte-derived macrophages) to central nervous system (CNS)-associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil-dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.
eng
Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
review
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Myeloid cells in vascular dementia_Br J Pharmacol_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/501e9eb4-bf45-4d8a-9f7a-fb735de8085b/download
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MD5
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Myeloid cells in vascular dementia_Br J Pharmacol_2023.pdf.txt