2026-04-29T04:09:04Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164032024-09-27T09:34:27Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Saez, Angela
author
Herrero-Fernandez, Beatriz
author
Gomez-Bris, Raquel
author
Sánchez-Martinez, Hector
author
Gonzalez-Granado, Jose M
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2023-09-04T14:35:56Z
2023-09-04T14:35:56Z
2023-01-12
Int J Mol Sci. 2023 Jan 12;24(2):1526.
http://hdl.handle.net/20.500.12105/16403
36675038
10.3390/ijms24021526
1422-0067
International journal of molecular sciences
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause. Intestinal innate immunity is enacted by neutrophils, monocytes, macrophages, and dendritic cells (DCs), and innate lymphoid cells and NK cells, characterized by their capacity to produce a rapid and nonspecific reaction as a first-line response. Innate immune cells (IIC) defend against pathogens and excessive entry of intestinal microorganisms, while preserving immune tolerance to resident intestinal microbiota. Changes to this equilibrium are linked to intestinal inflammation in the gut and IBD. IICs mediate host defense responses, inflammation, and tissue healing by producing cytokines and chemokines, activating the complement cascade and phagocytosis, or presenting antigens to activate the adaptive immune response. IICs exert important functions that promote or ameliorate the cellular and molecular mechanisms that underlie and sustain IBD. A comprehensive understanding of the mechanisms underlying these clinical manifestations will be important for developing therapies targeting the innate immune system in IBD patients. This review examines the complex roles of and interactions among IICs, and their interactions with other immune and non-immune cells in homeostasis and pathological conditions.
eng
Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.
review
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Pathophysiology of Inflammatory Int J Mol Sci_2023.pdf
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Pathophysiology of Inflammatory Int J Mol Sci_2023.pdf.txt