2026-04-18T17:37:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163922024-05-27T19:32:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Nakisli, Sera
author
Lagares, Alfonso
author
Nielsen, Corinne M
author
Cuervo, Henar
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-09-04T10:21:49Z
2023-09-04T10:21:49Z
2023
Front Physiol . 2023 Aug 4;14:1210563.
1664-042X
http://hdl.handle.net/20.500.12105/16392
37601628
10.3389/fphys.2023.1210563
Frontiers in physiology
Previously considered passive support cells, mural cells-pericytes and vascular smooth muscle cells-have started to garner more attention in disease research, as more subclassifications, based on morphology, gene expression, and function, have been discovered. Central nervous system (CNS) arteriovenous malformations (AVMs) represent a neurovascular disorder in which mural cells have been shown to be affected, both in animal models and in human patients. To study consequences to mural cells in the context of AVMs, various animal models have been developed to mimic and predict human AVM pathologies. A key takeaway from recently published work is that AVMs and mural cells are heterogeneous in their molecular, cellular, and functional characteristics. In this review, we summarize the observed perturbations to mural cells in human CNS AVM samples and CNS AVM animal models, and we discuss various potential mechanisms relating mural cell pathologies to AVMs.
eng
Pericytes and vascular smooth muscle cells in central nervous system arteriovenous malformations.
review
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https://repisalud.isciii.es/bitstreams/2e45cf51-6f1d-4586-bad1-c267f8042625/download
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Pericytes and vascular smooth_Front Physiol_2023.pdf
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https://repisalud.isciii.es/bitstreams/5ed98dd4-a6b3-460e-a484-13bafd909651/download
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Pericytes and vascular smooth_Front Physiol_2023.pdf.txt