2026-07-08T01:02:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163902024-05-27T19:32:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Fraga, Enrique
author
Medina, Violeta
author
Cuartero, María Isabel
author
García-Culebras, Alicia
author
Bravo-Ferrer, Isabel
author
Hernández-Jiménez, Macarena
author
Garcia-Segura, Juan Manuel
author
Hurtado, Olivia
author
Pradillo, Jesus Miguel
author
Lizasoain, Ignacio
author
Moro, María Ángeles
funder
Ministerio de Ciencia e Innovación (España)
funder
Fondation Leducq
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2023-09-04T09:39:17Z
2023-09-04T09:39:17Z
2023
Front Cell Neurosci. 2023 Aug 11;17:1219847
10.3389/fncel.2023.1219847
1662-5102
Frontiers in cellular neuroscience
37636586
http://hdl.handle.net/20.500.12105/16390
Chronic cerebral hypoperfusion due to carotid artery stenosis is a major cause of vascular cognitive impairment and dementia (VCID). Bilateral carotid artery stenosis (BCAS) in rodents is a well-established model of VCID where most studies have focused on white matter pathology and subsequent cognitive deficit. Therefore, our aim was to study the implication of adult hippocampal neurogenesis in hypoperfusion-induced VCID in mice, and its relationship with cognitive hippocampal deficits. Mice were subjected to BCAS; 1 and 3 months later, hippocampal memory and neurogenesis/cell death were assessed, respectively, by the novel object location (NOL) and spontaneous alternation performance (SAP) tests and by immunohistology. Hypoperfusion was assessed by arterial spin labeling-magnetic resonance imaging (ASL-MRI). Hypoperfused mice displayed spatial memory deficits with decreased NOL recognition index. Along with the cognitive deficit, a reduced number of newborn neurons and their aberrant morphology indicated a remarkable impairment of the hippocampal neurogenesis. Both increased cell death in the subgranular zone (SGZ) and reduced neuroblast proliferation rate may account for newborn neurons number reduction. Our data demonstrate quantitative and qualitative impairment of adult hippocampal neurogenesis disturbances associated with cerebral hypoperfusion-cognitive deficits in mice. These findings pave the way for novel diagnostic and therapeutic targets for VCID.
eng
Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice.
journal article
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Defective hippocampal neurogenesis_Front Cell Neurosci_2023.pdf
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https://repisalud.isciii.es/bitstreams/fb27be4e-3044-455f-b934-a24306ae67f1/download
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Defective hippocampal neurogenesis_Front Cell Neurosci_2023.pdf.txt