2026-04-29T17:02:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163842024-11-28T18:36:52Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_16977col_20.500.12105_19617
Repisalud
author
García-Martínez, José Manuel
author
Chocarro-Calvo, Ana
author
Martínez-Useros, Javier
author
Fernández-Aceñero, María Jesús
author
Fiuza, M Carmen
author
Cáceres-Rentero, José
author
De la Vieja, Antonio
author
Barbáchano, Antonio
author
Muñoz, Alberto
author
Larriba, María Jesús
author
García Jiménez, Custodia
funder
Agencia Estatal de Investigación (España)
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
King Juan Carlos University (España)
funder
Centro de Investigación Biomédica en Red - CIBERONC (Cáncer)
2023-08-31T15:47:59Z
2023-08-31T15:47:59Z
2023-08-02
Elife. 2023 Aug 2;12:RP86913.
10.7554/eLife.86913
2050-084X
eLife
37530744
http://hdl.handle.net/20.500.12105/16384
Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically associated with healthy aging and longevity, but its function in cancer is not well understood. Here, we reveal that 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3, calcitriol), the active metabolite of vitamin D (VD), promotes SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identify lysine 610 as an essential driver of SIRT1 activity. Remarkably, our data show that the post-translational control of SIRT1 activity mediates the antiproliferative action of 1,25(OH)2D3. This effect is reproduced by the SIRT1 activator SRT1720, suggesting that SIRT1 activators may offer new therapeutic possibilities for colon cancer patients who are VD deficient or unresponsive. Moreover, this might be extrapolated to inflammation and other VD deficiency-associated and highly prevalent diseases in which SIRT1 plays a prominent role.
eng
VDR
Acetylation
Cancer biology
Colorrectal cancer
Human
Vitamin D
Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
research article
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Vitamin_D_InducesSIRT1_2023.pdf
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https://repisalud.isciii.es/bitstreams/5eabb3c5-1a65-4106-a748-39032fd72e5d/download
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Vitamin_D_InducesSIRT1_2023.pdf.txt