2026-04-29T17:02:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/163842024-11-28T18:36:52Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_16977col_20.500.12105_19617

00925njm 22002777a 4500 dc García-Martínez, José Manuel author Chocarro-Calvo, Ana author Martínez-Useros, Javier author Fernández-Aceñero, María Jesús author Fiuza, M Carmen author Cáceres-Rentero, José author De la Vieja, Antonio author Barbáchano, Antonio author Muñoz, Alberto author Larriba, María Jesús author García Jiménez, Custodia author 2023-08-02 Posttranslational modifications of epigenetic modifiers provide a flexible and timely mechanism for rapid adaptations to the dynamic environment of cancer cells. SIRT1 is an NAD+-dependent epigenetic modifier whose activity is classically associated with healthy aging and longevity, but its function in cancer is not well understood. Here, we reveal that 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3, calcitriol), the active metabolite of vitamin D (VD), promotes SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identify lysine 610 as an essential driver of SIRT1 activity. Remarkably, our data show that the post-translational control of SIRT1 activity mediates the antiproliferative action of 1,25(OH)2D3. This effect is reproduced by the SIRT1 activator SRT1720, suggesting that SIRT1 activators may offer new therapeutic possibilities for colon cancer patients who are VD deficient or unresponsive. Moreover, this might be extrapolated to inflammation and other VD deficiency-associated and highly prevalent diseases in which SIRT1 plays a prominent role. Elife. 2023 Aug 2;12:RP86913. 10.7554/eLife.86913 2050-084X eLife 37530744 http://hdl.handle.net/20.500.12105/16384 VDR Acetylation Cancer biology Colorrectal cancer Human Vitamin D Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer