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oai:repisalud.isciii.es:20.500.12105/163802025-04-23T10:28:27Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud author Shaw, David author Abad, Raquel author Amin-Chowdhury, Zahin author Bautista, Adriana author Bennett, Desiree author Broughton, Karen author Cao, Bin author Casanova, Carlo author Choi, Eun Hwa author Chu, Yiu-Wai author Claus, Heike author Coelho, Juliana author Corcoran, Mary author Cottrell, Simon author Cunney, Robert author Cuypers, Lize author Dalby, Tine author Davies, Heather author de Gouveia, Linda author Deghmane, Ala-Eddine author Demczuk, Walter author Desmet, Stefanie author Domenech Lucas, Mirian author Drew, Richard author du Plessis, Mignon author Duarte, Carolina author Erlendsdóttir, Helga author Fry, Norman K author Fuursted, Kurt author Hale, Thomas author Henares, Desiree author Henriques-Normark, Birgitta author Hilty, Markus author Hoffmann, Steen author Humphreys, Hilary author Ip, Margaret author Jacobsson, Susanne author Johnson, Christopher author Johnston, Jillian author Jolley, Keith A author Kawabata, Aníbal author Kozakova, Jana author Kristinsson, Karl G author Křížová, Pavla author Kuch, Alicja author Ladhani, Shamez author Lâm, Thiên-Trí author León, María Eugenia author Lindholm, Laura author Litt, David author Maiden, Martin C J author Martin, Irene author Martiny, Delphine author Mattheus, Wesley author McCarthy, Noel D author Meehan, Mary author Meiring, Susan author Mölling, Paula author Morfeldt, Eva author Morgan, Julie author Mulhall, Robert author Muñoz-Almagro, Carmen author Murdoch, David author Murphy, Joy author Musilek, Martin author Mzabi, Alexandre author Novakova, Ludmila author Oftadeh, Shahin author Perez-Argüello, Amaresh author Perez-Vazquez, Maria author Perrin, Monique author Perry, Malorie author Prevost, Benoit author Roberts, Maria author Rokney, Assaf author Ron, Merav author Sanabria, Olga Marina author Scott, Kevin J author Sheppard, Carmen author Siira, Lotta author Sintchenko, Vitali author Skoczyńska, Anna author Sloan, Monica author Slotved, Hans-Christian author Smith, Andrew J author Steens, Anneke author Taha, Muhamed-Kheir author Toropainen, Maija author Tzanakaki, Georgina author Vainio, Anni author van der Linden, Mark P G author van Sorge, Nina M author Varon, Emmanuelle author Vohrnova, Sandra author von Gottberg, Anne author Yuste, Jose Enrique author Zanella, Rosemeire author Zhou, Fei author Brueggemann, Angela B funder Wellcome Trust funder NIHR - Oxford Biomedical Research Centre (Reino Unido) funder Ministerio de Ciencia e Innovación (España) funder Torsten Söderbergs Stiftelse funder Swedish Research Council funder Federal Ministry for Health (Alemania) funder Pfizer funder Merck KGaA funder Robert Koch Institute funder Korea Disease Control and Prevention Agency (Corea del Sur) funder National Public Health Organization (Grecia) funder Stockholm County Council 2023-08-30T12:05:00Z 2023-08-30T12:05:00Z 2023-09 Lancet Digit Health. 2023 Sep;5(9):e582-e593. 10.1016/S2589-7500(23)00108-5 2589-7500 The Lancet. Digital health 37516557 http://hdl.handle.net/20.500.12105/16380 Background: The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic. Methods: For this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere. Findings: Overall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0·47; 95% CI 0·40-0·55), H influenzae (0·51; 0·40-0·66) and N meningitidis (0·26; 0·21-0·31), while no significant changes were observed for S agalactiae (1·02; 0·75-1·40), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories. Interpretation: COVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies. eng Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium research article 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 URL https://repisalud.isciii.es/bitstreams/f8310bea-2a7f-422b-9808-fe41aa54963a/download File MD5 a9fd7ab395fd15810c71b3b9637888aa 2594572 application/pdf TrendsInvasiveBacterialDiseases_2023.pdf URL https://repisalud.isciii.es/bitstreams/efcce215-0071-467f-9058-9bb479f7197b/download File MD5 0cbe52e544b15b039fa9c8626771cf67 2338802 application/pdf Suplementary_TrendsInvasiveBacterialDiseases_2023.pdf URL https://repisalud.isciii.es/bitstreams/380965fc-2d2a-4fd6-b5e3-2334eddb4fe6/download File MD5 a5147046a6a5c0a91b7b1d1c841b2d0d 67545 text/plain TrendsInvasiveBacterialDiseases_2023.pdf.txt URL https://repisalud.isciii.es/bitstreams/6ff124d1-51b2-4649-a4f9-c5a390d72758/download File MD5 13930691065e231b072557de8f9e51b1 5115 text/plain Suplementary_TrendsInvasiveBacterialDiseases_2023.pdf.txt