2026-06-14T02:29:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163632024-11-28T16:13:46Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Municio, Cristina
author
Carrero, Laura
author
Antequera, Desireé
author
Carro, Eva
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
funder
Fundacion Española para la Investigación en Parkinson
2023-08-28T14:39:51Z
2023-08-28T14:39:51Z
2023-01-03
Int J Mol Sci. 2023 Jan 3;24(1):878.
10.3390/ijms24010878
1422-0067
International journal of molecular sciences
36614315
http://hdl.handle.net/20.500.12105/16363
The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is known to be impaired in neurological disorders, including Alzheimer's disease (AD). For this reason, it is important to understand the specific mechanisms and factors controlling glymphatic function. This pathway enables the flow of cerebrospinal fluid (CSF) into the brain and subsequently the brain interstitium, supported by aquaporins (AQPs). Continuous CSF transport through the brain parenchyma is critical for the effective transport and drainage of waste solutes, such as toxic proteins, through the glymphatic system. However, a balance between CSF production and secretion from the choroid plexus, through AQP regulation, is also needed. Thus, any condition that affects CSF homeostasis will also interfere with effective waste removal through the clearance glymphatic pathway and the subsequent processes of neurodegeneration. In this review, we highlight the role of AQPs in the choroid plexus in the modulation of CSF homeostasis and, consequently, the glymphatic clearance pathway, with a special focus on AD.
eng
Alzheimer’s disease
Aquaporins
Astrocytes
Cerebrospinal fluid
Choroid plexus
Clearance
Glymphatic system
Homeostasis
Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer's Disease
review article
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ChoroidPlexusAquaporinsCSF_2023.pdf
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ChoroidPlexusAquaporinsCSF_2023.pdf.txt
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