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00925njm 22002777a 4500 dc Municio, Cristina author Carrero, Laura author Antequera, Desireé author Carro, Eva author 2023-01-03 The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is known to be impaired in neurological disorders, including Alzheimer's disease (AD). For this reason, it is important to understand the specific mechanisms and factors controlling glymphatic function. This pathway enables the flow of cerebrospinal fluid (CSF) into the brain and subsequently the brain interstitium, supported by aquaporins (AQPs). Continuous CSF transport through the brain parenchyma is critical for the effective transport and drainage of waste solutes, such as toxic proteins, through the glymphatic system. However, a balance between CSF production and secretion from the choroid plexus, through AQP regulation, is also needed. Thus, any condition that affects CSF homeostasis will also interfere with effective waste removal through the clearance glymphatic pathway and the subsequent processes of neurodegeneration. In this review, we highlight the role of AQPs in the choroid plexus in the modulation of CSF homeostasis and, consequently, the glymphatic clearance pathway, with a special focus on AD. Int J Mol Sci. 2023 Jan 3;24(1):878. 10.3390/ijms24010878 1422-0067 International journal of molecular sciences 36614315 http://hdl.handle.net/20.500.12105/16363 Alzheimer’s disease Aquaporins Astrocytes Cerebrospinal fluid Choroid plexus Clearance Glymphatic system Homeostasis Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer's Disease