2026-06-14T03:51:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163502024-09-28T02:15:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Perez-Luz, Sara
author
Matamala, Nerea
author
Gomez-Mariano, Gema Maria
author
Janciauskiene, Sabina
author
Martinez-Delgado, Beatriz
funder
Instituto de Salud Carlos III
funder
Foundation for Polish Science
2023-08-25T13:39:46Z
2023-08-25T13:39:46Z
2023-07-12
Biomedicines. 2023 Jul 12;11(7):1961.
10.3390/biomedicines11071961
2227-9059
Biomedicines
37509601
http://hdl.handle.net/20.500.12105/16350
Non-alcoholic fatty liver disease (NAFLD) is a type of steatosis commonly associated with obesity, dyslipidemia, hypertension, and diabetes. Other diseases such as inherited alpha-1 antitrypsin deficiency (AATD) have also been related to the development of liver steatosis. The primary reasons leading to hepatic lipid deposits can be genetic and epigenetic, and the outcomes range from benign steatosis to liver failure, as well as to extrahepatic diseases. Progressive hepatocellular damage and dysregulated systemic immune responses can affect extrahepatic organs, specifically the heart and lungs. In this review, we discuss the similarities and differences between the molecular pathways of NAFLD and AATD, and the putative value of hepatic organoids as novel models to investigate the physio pathological mechanisms of liver steatosis.
eng
AATD
NAFLD
Cardiovascular disease
Lipids
Meta-inflammation
NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences
review article
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URL
https://repisalud.isciii.es/bitstreams/e88b4a0a-d87c-48ea-899c-176624f4fae5/download
File
MD5
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application/pdf
NAFLD_AATD_AreTwoDiseases_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/a52db1fa-f8d4-4dc8-8d7e-ae43b94e8511/download
File
MD5
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text/plain
NAFLD_AATD_AreTwoDiseases_2023.pdf.txt