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oai:repisalud.isciii.es:20.500.12105/163502024-09-28T02:15:55Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616

00925njm 22002777a 4500 dc Perez-Luz, Sara author Matamala, Nerea author Gomez-Mariano, Gema Maria author Janciauskiene, Sabina author Martinez-Delgado, Beatriz author 2023-07-12 Non-alcoholic fatty liver disease (NAFLD) is a type of steatosis commonly associated with obesity, dyslipidemia, hypertension, and diabetes. Other diseases such as inherited alpha-1 antitrypsin deficiency (AATD) have also been related to the development of liver steatosis. The primary reasons leading to hepatic lipid deposits can be genetic and epigenetic, and the outcomes range from benign steatosis to liver failure, as well as to extrahepatic diseases. Progressive hepatocellular damage and dysregulated systemic immune responses can affect extrahepatic organs, specifically the heart and lungs. In this review, we discuss the similarities and differences between the molecular pathways of NAFLD and AATD, and the putative value of hepatic organoids as novel models to investigate the physio pathological mechanisms of liver steatosis. Biomedicines. 2023 Jul 12;11(7):1961. 10.3390/biomedicines11071961 2227-9059 Biomedicines 37509601 http://hdl.handle.net/20.500.12105/16350 AATD NAFLD Cardiovascular disease Lipids Meta-inflammation NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences