2026-05-22T00:55:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163372025-05-08T10:56:00Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958
Repisalud
author
Mingo-Casas, Patricia
author
Sánchez-Céspedes, Javier
author
Blázquez, Ana-Belén
author
Casas, Josefina
author
Balsera-Manzanero, María
author
Herrero-Romero, Laura
author
Vazquez, Ana
author
Pachón, Jerónimo
author
Aguilar-Guisado, Manuela
author
Cisneros, José Miguel
author
Saiz, Juan-Carlos
author
Martín-Acebes, Miguel A
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea
2023-08-24T10:37:39Z
2023-08-24T10:37:39Z
2023
Emerg Microbes Infect. 2023 Dec;12(2):2231.
10.1080/22221751.2023.2231556
2222-1751
Emerging microbes & infections
37377355
http://hdl.handle.net/20.500.12105/16337
West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding of the physiopathology associated with disease progression is mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma and serum) constitute the more commonly used biofluids due to its ease of collection and high value for diagnostic purposes. Therefore, the potential impact of this virus in the circulating lipidome was addressed combining the analysis of samples from experimentally infected mice and naturally WND patients. Our results unveil dynamic alterations in the lipidome that define specific metabolic fingerprints of different infection stages. Concomitant with neuroinvasion in mice, the lipid landscape was dominated by a metabolic reprograming that resulted in significant elevations of circulating sphingolipids (ceramides, dihydroceramides, and dihydrosphingomyelins), phosphatidylethanolamines and triacylglycerols. Remarkably, patients suffering from WND also displayed an elevation of ceramides, dihydroceramides, lactosylceramides, and monoacylglycerols in their sera. The dysregulation of sphingolipid metabolism by WNV may provide new therapeutic opportunities and supports the potential of certain lipids as novel peripheral biomarkers of WND progression.
eng
West Nile virus
Viral infection
Lipid
Patient
Biomarker
Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers
research article
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