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00925njm 22002777a 4500 dc Palomar-Cros, Anna author Straif, Kurt author Romaguera, Dora author Aragones, Nuria author Castaño-Vinyals, Gemma author Martín, Vicente author Moreno, Victor author Gómez-Acebo, Inés author Guevara, Marcela author Aizpurua, Amaia author Molina-Barceló, Ana author Jimenez-Moleon, Jose J. author Tardón, Adonina author Contreras-Llanes, Manuel author Marcos-Gragera, Rafael author Huerta, José María author Perez-Gomez, Beatriz author Espinosa, Ana author Hernández-Segura, Natalia author Obón-Santacana, Mireia author Alonso-Molero, Jéssica author Burgui, Rosana author Amiano, Pilar author Pinto-Carbó, Marina author Olmedo-Requena, Rocío author Fernández-Tardón, Guillermo author Santos-Sánchez, Vanessa author Fernandez de Larrea-Baz, Nerea author Fernández-Villa, Tania author Casabonne, Delphine author Dierssen-Sotos, Trinidad author Ardanaz, Eva author Dorronsoro, Ane author Pollan-Santamaria, Marina author Kogevinas, Manolis author Lassale, Camille author 2023-09-01 Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes. Int J Cancer. 2023 Sep 1;153(5):979-993. 10.1002/ijc.34577 1097-0215 International journal of cancer https://hdl.handle.net/20.500.13003/19068 37323037 L2023865904 2-s2.0-85162002355 http://hdl.handle.net/20.500.12105/16328 1021495500001 Artificial sweeteners Aspartame Cancer risk Case-control Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)