2026-08-29T19:28:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163122024-09-28T00:11:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud
author
Leese, Elizabeth
author
Jones, Kate
author
Bocca, Beatrice
author
Bousoumah, Radia
author
Castaño, Argelia
author
Galea, Karen S
author
Iavicoli, Ivo
author
Esteban-Lopez, Marta
author
Leso, Veruscka
author
Ndaw, Sophie
author
Porras, Simo P
author
Ruggieri, Flavia
author
Scheepers, Paul T J
author
Santonen, Tiina
author
HBM4EU chromates study team
funder
Unión Europea. Comisión Europea. H2020
2023-07-25T08:34:18Z
2023-07-25T08:34:18Z
2023-02-15
Toxicol Lett. 2023 Feb 15;375:59-68.
10.1016/j.toxlet.2022.12.009
1879-3169
Toxicology letters
36535516
http://hdl.handle.net/20.500.12105/16312
The aim of this study was to investigate the practicability of exhaled breath condensate (EBC) as a biological matrix to detect and measure hexavalent chromium (Cr(VI)) and trivalent chromium (Cr(III)) in workers occupationally exposed to Cr(VI). EBC samples were collected from workers in France, Finland, Italy, The Netherlands and the United Kingdom from three different target activities: chrome platers, stainless steel welders and surface treatment workers. Pre and post working week EBC samples were collected from 177 exposed workers and 98 unexposed workers (control group). Hyphenated chromatography systems with inductively coupled plasma - mass spectrometry (ICP-MS) were for the analysis. The results showed that the occupationally exposed workers had significantly higher levels of Cr(VI) and Cr(III) than the control group. Chrome platers exhibited the highest Cr(VI) levels in their EBC samples, with a significant increase from their pre to post samples for both Cr(VI) and Cr(III). A significant difference was also found between pre and post EBC samples for Cr(III) in welders. This study has shown that EBC has the potential to be a valid, non-invasive biological matrix to assess occupational exposure to Cr(VI) and Cr(III) for biological monitoring assessment, with the ability to detect low level inhalation exposures.
eng
Chrome platers
Chromium speciation
EBC
Human biomonitoring
Welders
HBM4EU chromates study - the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe
research article
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