2026-08-29T20:25:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/163122024-09-28T00:11:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Leese, Elizabeth author Jones, Kate author Bocca, Beatrice author Bousoumah, Radia author Castaño, Argelia author Galea, Karen S author Iavicoli, Ivo author Esteban-Lopez, Marta author Leso, Veruscka author Ndaw, Sophie author Porras, Simo P author Ruggieri, Flavia author Scheepers, Paul T J author Santonen, Tiina author HBM4EU chromates study team author 2023-02-15 The aim of this study was to investigate the practicability of exhaled breath condensate (EBC) as a biological matrix to detect and measure hexavalent chromium (Cr(VI)) and trivalent chromium (Cr(III)) in workers occupationally exposed to Cr(VI). EBC samples were collected from workers in France, Finland, Italy, The Netherlands and the United Kingdom from three different target activities: chrome platers, stainless steel welders and surface treatment workers. Pre and post working week EBC samples were collected from 177 exposed workers and 98 unexposed workers (control group). Hyphenated chromatography systems with inductively coupled plasma - mass spectrometry (ICP-MS) were for the analysis. The results showed that the occupationally exposed workers had significantly higher levels of Cr(VI) and Cr(III) than the control group. Chrome platers exhibited the highest Cr(VI) levels in their EBC samples, with a significant increase from their pre to post samples for both Cr(VI) and Cr(III). A significant difference was also found between pre and post EBC samples for Cr(III) in welders. This study has shown that EBC has the potential to be a valid, non-invasive biological matrix to assess occupational exposure to Cr(VI) and Cr(III) for biological monitoring assessment, with the ability to detect low level inhalation exposures. Toxicol Lett. 2023 Feb 15;375:59-68. 10.1016/j.toxlet.2022.12.009 1879-3169 Toxicology letters 36535516 http://hdl.handle.net/20.500.12105/16312 Chrome platers Chromium speciation EBC Human biomonitoring Welders HBM4EU chromates study - the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe