2026-05-21T23:39:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/163082024-09-27T23:56:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Obando, Ignacio
author
Muñoz-Almagro, Carmen
author
Arroyo, Luis A
author
Tarrago Asensio, David
author
Sanchez-Tatay, David
author
Moreno-Perez, David
author
Dhillon, Sahar S
author
Esteva, Cristina
author
Hernandez-Bou, Susanna
author
Garcia-Garcia, Juan J
author
Hausdorff, William P
author
Brueggemann, Angela B
funder
Instituto de Salud Carlos III
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
GlaxoSmithKline
funder
Fundación CajaSol
funder
Regional Government of Andalusia (España)
2023-07-25T06:49:51Z
2023-07-25T06:49:51Z
2008-09
Emerg Infect Dis. 2008 Sep;14(9):1390-7.
10.3201/eid1409.071094
1080-6059
Emerging infectious diseases
18760005
http://hdl.handle.net/20.500.12105/16308
Pediatric parapneumonic empyema (PPE) has been increasing in several countries including Spain. Streptococcus pneumoniae is a major PPE pathogen; however, antimicrobial pretreatment before pleural fluid (PF) sampling frequently results in negative diagnostic cultures, thus greatly underestimating the contribution of pneumococci, especially pneumococci susceptible to antimicrobial agents, to PPE. The study aim was to identify the serotypes and genotypes that cause PPE by using molecular diagnostics and relate these data to disease incidence and severity. A total of 208 children with PPE were prospectively enrolled; blood and PF samples were collected. Pneumococci were detected in 79% of culture-positive and 84% of culture-negative samples. All pneumococci were genotyped by multilocus sequence typing. Serotypes were determined for 111 PPE cases; 48% were serotype 1, of 3 major genotypes previously circulating in Spain. Variance in patient complication rates was statistically significant by serotype. The recent PPE increase is principally due to nonvaccine serotypes, especially the highly invasive serotype 1.
eng
Pediatric parapneumonic empyema, Spain
research article
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PediatricParapneumonicEmpyemaSpain_2008.pdf
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PediatricParapneumonicEmpyemaSpain_2008.pdf.txt