2026-05-22T05:31:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/162872024-11-28T19:23:40Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16977

00925njm 22002777a 4500 dc Del Rosal, Teresa author García-García, María Luz author Casas Flecha, Inmaculada author Iglesias-Caballero, Maria author Pozo Sanchez, Francisco author Alcolea, Sonia author Bravo, Blanca author Rodrigo-Muñoz, José M author Del Pozo, Victoria author Calvo, Cristina author 2023-03-01 Background: Torque teno virus (TTV) is a ubiquitous anellovirus responsible for persistent infections and is considered a marker of immune function. The role of TTV as a facilitator of respiratory infections (RIs) is unknown. Objectives: Our aim was to estimate, in a prospective study, the prevalence of TTV in the nasopharyngeal aspirate (NPA) of hospitalized children <5 years old, with RIs and correlate them with outcomes and immune response. Patients and methods: NPA was taken for testing of 16 respiratory viruses by reverse transcription-polymerase chain reaction (PCR), TTV PCR, and immunologic study. Results: Sixty hospitalized children with an RI were included. A total of 51/60 patients had positive common respiratory viral (CRV) identification. A total of 23/60 (38.3%) children were TTV+ in NPA. TTV+ patients had other CRVs in 100% of cases versus 78.3% in TTV- ( P = 0.029). The TTV+ patients tended to be older, have fever, and to need pediatric intensive care unit admission more often than TTV- patients. Abnormal chest radiograph was more frequent in the TTV+ patients, odds ratios 2.6 (95% CI: 1.3-5.2). The genetic expression of filaggrin (involved in epithelial barrier integrity) was lower in TTV+ patients; however, the levels of filaggrin in the NPA were increased. Conclusions: TTV infection is common in children with RI and could be associated with abnormal imaging in radiograph, greater severity and an alteration in filaggrin gene expression and protein release. Pediatr Infect Dis J. 2023 Mar 1;42(3):184-188. 10.1097/INF.0000000000003796 1532-0987 The Pediatric infectious disease journal 36729788 http://hdl.handle.net/20.500.12105/16287 Torque teno virus Infants Viral respiratory infections Torque Teno Virus in Nasopharyngeal Aspirate of Children With Viral Respiratory Infections