2026-05-19T13:17:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162802024-09-27T08:04:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Zuriaga, María A
author
Fuster, Jose J.
funder
Ministerio de Ciencia e Innovación (España)
funder
European Research Area Network on Cardiovascular Diseases
funder
Instituto de Salud Carlos III
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Fondation Leducq
2023-07-17T13:38:53Z
2023-07-17T13:38:53Z
2023-02-24
Circ J. 2023 Feb 24;87(3):394-400
10.1253/circj.CJ-21-0505
1347-4820
1346-9843
Circulation journal : official journal of the Japanese Circulation Society
34433749
http://hdl.handle.net/20.500.12105/16280
Accumulating evidence suggests that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, as a substantial risk remains even when these factors are apparently managed well. In this context, clonal hematopoiesis has emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiometabolic conditions. Clonal hematopoiesis typically arises from somatic mutations that confer a competitive advantage to a mutant hematopoietic stem cell, leading to its clonal expansion in the stem cell population and its progeny of blood leukocytes. Human sequencing studies and experiments in mice suggest that clonal hematopoiesis, at least when driven by certain mutations, contributes to accelerated atherosclerosis development. However, the epidemiology, biology and clinical implications of this phenomenon remain incompletely understood. Here, we review the current understanding of the connection between clonal hematopoiesis and atherosclerosis, and highlight knowledge gaps in this area of research.
eng
Emerging Role of Acquired Mutations and Clonal Hematopoiesis in Atherosclerosis - Beyond Conventional Cardiovascular Risk Factors.
research article
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Emerging Role of Acquired_Circ J_2023.pdf
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Emerging Role of Acquired_Circ J_2023.pdf.txt