2026-04-18T14:00:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162732024-09-27T08:23:14Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Romero-Miguel, Diego
author
Casquero-Veiga, Marta
author
Fernández, Javier
author
Lamanna-Rama, Nicolás
author
Gómez-Rangel, Vanessa
author
Gálvez-Robleño, Carlos
author
Santa-Marta, Cristina
author
Villar, Claudio J
author
Lombó, Felipe
author
Abalo, Raquel
author
Desco, Manuel
author
Soto-Montenegro, María Luisa
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Plan Nacional de Drogas (España)
funder
Fundación Alicia Koplowitz
funder
Fundación Tatiana Pérez de Guzmán el Bueno
funder
Instituto de Investigación Sanitaria Gregorio Marañón
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Gobierno del Principado de Asturias (España)
2023-07-17T11:27:27Z
2023-07-17T11:27:27Z
2023-04-20
Antioxidants (Basel). 2023 Apr 20;12(4):970
2076-3921
http://hdl.handle.net/20.500.12105/16273
37107344
10.3390/antiox12040970
Antioxidants (Basel, Switzerland)
The microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.
eng
Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.
research article
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URL
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Maternal Supplementation Antioxidants_Basel_2023.pdf
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https://repisalud.isciii.es/bitstreams/3ffc9e69-1fa0-423f-905a-e28d604c091d/download
File
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text/plain
Maternal Supplementation Antioxidants_Basel_2023.pdf.txt