2026-05-25T03:29:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162632024-09-27T08:31:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Raiola, Morena
author
Sendra, Miquel
author
Torres, Miguel
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Comisión Europea. H2020
funder
Fundación La Caixa
funder
Fundación ProCNIC
2023-07-17T10:03:03Z
2023-07-17T10:03:03Z
2023-03-29
J Cardiovasc Dev Dis. 2023 Mar 29;10(4):145
10.3390/jcdd10040145
2308-3425
Journal of cardiovascular development and disease
37103024
http://hdl.handle.net/20.500.12105/16263
Heart morphogenesis is a complex and dynamic process that has captivated researchers for almost a century. This process involves three main stages, during which the heart undergoes growth and folding on itself to form its common chambered shape. However, imaging heart development presents significant challenges due to the rapid and dynamic changes in heart morphology. Researchers have used different model organisms and developed various imaging techniques to obtain high-resolution images of heart development. Advanced imaging techniques have allowed the integration of multiscale live imaging approaches with genetic labeling, enabling the quantitative analysis of cardiac morphogenesis. Here, we discuss the various imaging techniques used to obtain high-resolution images of whole-heart development. We also review the mathematical approaches used to quantify cardiac morphogenesis from 3D and 3D+time images and to model its dynamics at the tissue and cellular levels.
eng
Imaging Approaches and the Quantitative Analysis of Heart Development.
review
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URL
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Imaging Approaches and the Quantitative_J Cardiovasc Dev Dis_2023.pdf
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Imaging Approaches and the Quantitative_J Cardiovasc Dev Dis_2023.pdf.txt