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oai:repisalud.isciii.es:20.500.12105/162632024-09-27T08:31:28Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Raiola, Morena author Sendra, Miquel author Torres, Miguel author 2023-03-29 Heart morphogenesis is a complex and dynamic process that has captivated researchers for almost a century. This process involves three main stages, during which the heart undergoes growth and folding on itself to form its common chambered shape. However, imaging heart development presents significant challenges due to the rapid and dynamic changes in heart morphology. Researchers have used different model organisms and developed various imaging techniques to obtain high-resolution images of heart development. Advanced imaging techniques have allowed the integration of multiscale live imaging approaches with genetic labeling, enabling the quantitative analysis of cardiac morphogenesis. Here, we discuss the various imaging techniques used to obtain high-resolution images of whole-heart development. We also review the mathematical approaches used to quantify cardiac morphogenesis from 3D and 3D+time images and to model its dynamics at the tissue and cellular levels. J Cardiovasc Dev Dis. 2023 Mar 29;10(4):145 10.3390/jcdd10040145 2308-3425 Journal of cardiovascular development and disease 37103024 http://hdl.handle.net/20.500.12105/16263 Imaging Approaches and the Quantitative Analysis of Heart Development.