2026-07-15T15:52:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162592024-09-27T09:53:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Ovadia, Samuel
author
Özcan, Alaz
author
Hidalgo, Andres
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea
funder
Swiss National Science Foundation
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-07-17T09:24:47Z
2023-07-17T09:24:47Z
2023-06-01
J Leukoc Biol. 2023 Jun 1;113(6):555-566
10.1093/jleuko/qiad038
1938-3673
Journal of leukocyte biology
36999376
http://hdl.handle.net/20.500.12105/16259
The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.
eng
The circadian neutrophil, inside-out.
review
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URL
https://repisalud.isciii.es/bitstreams/caadf4c4-9f9f-4054-a10e-3bd21789287f/download
File
MD5
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application/pdf
The circadian neutrophil J Leukoc Biol_ 2023.pdf
URL
https://repisalud.isciii.es/bitstreams/02322242-c710-4709-bde3-96f5e6ae7bd6/download
File
MD5
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The circadian neutrophil J Leukoc Biol_ 2023.pdf.txt