2026-07-15T15:52:41Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/162592024-09-27T09:53:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Ovadia, Samuel author Özcan, Alaz author Hidalgo, Andres author 2023-06-01 The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity. J Leukoc Biol. 2023 Jun 1;113(6):555-566 10.1093/jleuko/qiad038 1938-3673 Journal of leukocyte biology 36999376 http://hdl.handle.net/20.500.12105/16259 The circadian neutrophil, inside-out.