2026-05-13T08:35:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162582024-09-27T08:52:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Real, Carlos
author
Párraga, Rocío
author
Pizarro, Gonzalo
author
García-Lunar, Inés
author
González-Calvo, Ernesto
author
Martínez-Gómez, Jesús
author
Sánchez-González, Javier
author
Sampedro, Patricia
author
Sanmamed, Irene
author
De Miguel, Mercedes
author
De Cos-Gandoy, Amaya
author
Bodega, Patricia
author
Ibáñez, Borja
author
Santos-Beneit, Gloria
author
Fuster, Valentin
author
Fernández-Jiménez, Rodrigo
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Educación y Cultura (España)
funder
Fundación La Caixa
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-07-17T09:09:22Z
2023-07-17T09:09:22Z
2023-03
EClinicalMedicine. 2023 Mar 3;57:101885
10.1016/j.eclinm.2023.101885
2589-5370
EClinicalMedicine
37064511
http://hdl.handle.net/20.500.12105/16258
BACKGROUND
Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population.
METHODS
Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021. The imaging protocol included a cine steady-state free-precession sequence for the analysis of chamber size and function, as well as T2-GraSE and native MOLLI T1-mapping for the characterization of myocardial tissue.
FINDINGS
CMR scans were performed in 123 adolescents (mean age 16 ± 0.5 years, 52% girls). Mean left and right ventricular end-diastolic indexed volumes were higher in boys than in girls (91.7 ± 11.6 vs 78.1 ± 8.3 ml/m2, p < 0.001; and 101.3 ± 14.1 vs 84.1 ± 10.5 ml/m2, p < 0.001), as was the indexed left ventricular mass (48.5 ± 9.6 vs 36.6 ± 6.0 g/m2, p < 0.001). Left ventricular ejection fraction showed no significant difference by sex (62.2 ± 4.1 vs 62.8 ± 4.2%, p = 0.412), whereas right ventricular ejection fraction trended slightly lower in boys (55.4 ± 4.7 vs. 56.8 ± 4.4%, p = 0.085). Indexed atrial size and function parameters did not differ significantly between sexes. Global myocardial native T1 relaxation time was lower in boys than in girls (1215 ± 23 vs 1252 ± 28 ms, p < 0.001), whereas global myocardial T2 relaxation time did not differ by sex (44.4 ± 2.0 vs 44.1 ± 2.4 ms, p = 0.384). Sex-stratified comprehensive percentile tables are provided for most relevant cardiac parameters.
INTERPRETATION
This cross-sectional study provides overall and sex-stratified CMR reference values for cardiac dimensions and function, and myocardial tissue properties, in adolescents. This information is useful for clinical practice and may help in the differential diagnosis of cardiac diseases, such as cardiomyopathies and myocarditis, in this population.
FUNDING
Instituto de Salud Carlos III (PI19/01704).
eng
Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.
journal article
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Magnetic resonance imaging EClinicalMedicine_2023.pdf.txt