2026-05-21T23:00:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162422025-05-08T12:50:29Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Segura-Collar, Berta
author
Hiller-Vallina, Sara
author
Dios Huerta, Olaya de
author
Caamaño-Moreno, Marta
author
Mondejar-Ruescas, Lucia
author
Sepúlveda-Sánchez, Juan Manuel
author
Gargini, Ricardo
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Ciencia e Innovación (España)
2023-07-13T16:16:06Z
2023-07-13T16:16:06Z
2023-05-10
Acta Neuropathol Commun. 2023 May 10;11(1):79.
10.1186/s40478-023-01569-y
2051-5960
Acta neuropathologica communications
37165457
http://hdl.handle.net/20.500.12105/16242
Glial-origin brain tumors, including glioblastomas (GBM), have one of the worst prognoses due to their rapid and fatal progression. From an oncological point of view, advances in complete surgical resection fail to eliminate the entire tumor and the remaining cells allow a rapid recurrence, which does not respond to traditional therapeutic treatments. Here, we have reviewed new immunotherapy strategies in association with the knowledge of the immune micro-environment. To understand the best lines for the future, we address the advances in the design of neoantigen vaccines and possible new immune modulators. Recently, the efficacy and availability of vaccine development with different formulations, especially liposome plus mRNA vaccines, has been observed. We believe that the application of new strategies used with mRNA vaccines in combination with personalized medicine (guided by different omic's strategies) could give good results in glioma therapy. In addition, a large part of the possible advances in new immunotherapy strategies focused on GBM may be key improving current therapies of immune checkpoint inhibitors (ICI), given the fact that this type of tumor has been highly refractory to ICI.
eng
Glioblastoma
Glioma
Neoantigen vaccine
mRNA vaccine
Virotherapy
Immunotherapy
Tumor microenvironment
Suppressive myeloid cells
Immune checkpoint inhibitors
PD-1
PD-L1
Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators
review article
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Erratum_AdvancedImmunotherapiesGlioblastomaTumor_2023.pdf
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AdvancedImmunotherapiesGlioblastomaTumor_2023.pdf.txt
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