2026-06-14T05:08:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/162332025-04-04T17:15:57Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_16966col_20.500.12105_19617
Repisalud
author
Torres Iglesias, Gabriel
author
Fernández-Fournier, Mireya
author
Botella, Lucía
author
Piniella, Dolores
author
Laso-García, Fernando
author
Gómez-de Frutos, Mari Carmen
author
Chamorro, Beatriz
author
Puertas, Inmaculada
author
Tallón Barranco, Antonio
author
Fuentes, Blanca
author
Alonso de Leciñana, Maria
author
Alonso-López, Elisa
author
Bravo, Susana-Belén
author
Miranda-Carús, María Eugenia
author
Montero-Calle, Ana Maria
author
Barderas Manchado, Rodrigo
author
Díez-Tejedor, Exuperio
author
Gutiérrez-Fernández, María
author
Otero-Ortega, Laura
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Universidades (España)
funder
Autonomous University of Madrid (España)
2023-07-13T09:51:43Z
2023-07-13T09:51:43Z
2023
Brain Behav Immun. 2023 Oct;113:44-55.
10.1016/j.bbi.2023.06.025
1090-2139
Brain, behavior, and immunity
37406976
http://hdl.handle.net/20.500.12105/16233
Background: Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend the disease's pathogenesis is crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease's pathological processes. Purpose: To identify the immune and nervous system-derived EV profile from blood that could have a specific role as biomarker in MS and assess its possible correlation with disease state. Results: Higher levels of T cell-derived EVs and smaller size of neuron-derived EVs were associated with clinical relapse. The smaller size of the oligodendrocyte-derived EVs was related with motor and cognitive impairment. The proteomic analysis identified mannose-binding lectin serine protease 1 and complement factor H from immune system cell-derived EVs as autoimmune disease-associated proteins. We observed hepatocyte growth factor-like protein in EVs from T cells and inter-alpha-trypsin inhibitor heavy chain 2 from neurons as white matter injury-related proteins. In patients with MS, a specific protein profile was found in the EVs, higher levels of alpha-1-microglobulin and fibrinogen β chain, lower levels of C1S and gelsolin in the immune system-released vesicles, and Talin-1 overexpression in oligodendrocyte EVs. These specific MS-associated proteins, as well as myelin basic protein in oligodendrocyte EVs, correlated with disease activity in the patients with MS. Conclusion: Neural-derived and immune-derived EVs found in blood appear to be good specific biomarkers in MS for reflecting the disease state.
eng
Biomarkers
Blood
Exosomes
Extracellular Vesicles
Multiple Sclerosis
Proteomic Analysis
Rheumatoid Arthritis
Subcortical Stroke
Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis
research article
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