2026-04-29T06:16:11Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/162332025-04-04T17:15:57Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16963col_20.500.12105_16966col_20.500.12105_19617

00925njm 22002777a 4500 dc Torres Iglesias, Gabriel author Fernández-Fournier, Mireya author Botella, Lucía author Piniella, Dolores author Laso-García, Fernando author Gómez-de Frutos, Mari Carmen author Chamorro, Beatriz author Puertas, Inmaculada author Tallón Barranco, Antonio author Fuentes, Blanca author Alonso de Leciñana, Maria author Alonso-López, Elisa author Bravo, Susana-Belén author Miranda-Carús, María Eugenia author Montero-Calle, Ana Maria author Barderas Manchado, Rodrigo author Díez-Tejedor, Exuperio author Gutiérrez-Fernández, María author Otero-Ortega, Laura author 2023 Background: Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend the disease's pathogenesis is crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease's pathological processes. Purpose: To identify the immune and nervous system-derived EV profile from blood that could have a specific role as biomarker in MS and assess its possible correlation with disease state. Results: Higher levels of T cell-derived EVs and smaller size of neuron-derived EVs were associated with clinical relapse. The smaller size of the oligodendrocyte-derived EVs was related with motor and cognitive impairment. The proteomic analysis identified mannose-binding lectin serine protease 1 and complement factor H from immune system cell-derived EVs as autoimmune disease-associated proteins. We observed hepatocyte growth factor-like protein in EVs from T cells and inter-alpha-trypsin inhibitor heavy chain 2 from neurons as white matter injury-related proteins. In patients with MS, a specific protein profile was found in the EVs, higher levels of alpha-1-microglobulin and fibrinogen β chain, lower levels of C1S and gelsolin in the immune system-released vesicles, and Talin-1 overexpression in oligodendrocyte EVs. These specific MS-associated proteins, as well as myelin basic protein in oligodendrocyte EVs, correlated with disease activity in the patients with MS. Conclusion: Neural-derived and immune-derived EVs found in blood appear to be good specific biomarkers in MS for reflecting the disease state. Brain Behav Immun. 2023 Oct;113:44-55. http://hdl.handle.net/20.500.12105/16233 37406976 10.1016/j.bbi.2023.06.025 1090-2139 Brain, behavior, and immunity Biomarkers Blood Exosomes Extracellular Vesicles Multiple Sclerosis Proteomic Analysis Rheumatoid Arthritis Subcortical Stroke Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis