2026-06-14T03:31:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/161932025-04-07T11:19:28Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Trickey, Adam
author
Ingle, Suzanne M
author
Boyd, Anders
author
Gill, M John
author
Grabar, Sophie
author
Jarrin Vera, Inmaculada
author
Obel, Niels
author
Touloumi, Giota
author
Zangerle, Robert
author
Rauch, Andri
author
Rentsch, Christopher T
author
Satre, Derek D
author
Silverberg, Michael J
author
Bonnet, Fabrice
author
Guest, Jodie
author
Burkholder, Greer
author
Crane, Heidi
author
Teira, Ramon
author
Berenguer, Juan
author
Wyen, Christoph
author
Abgrall, Sophie
author
Hessamfar, Mojgan
author
Reiss, Peter
author
d'Arminio Monforte, Antonella
author
McGinnis, Kathleen A
author
Sterne, Jonathan A C
author
Wittkop, Linda
author
Antiretroviral Therapy Cohort Collaboration (ART-CC)
funder
NIH - National Institute on Alcohol Abuse and Alcoholism (NIAAA) (Estados Unidos)
funder
NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)
funder
United States Department of Veterans Affairs
funder
Instituto de Salud Carlos III
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Swiss National Science Foundation
funder
Ministerio de Sanidad (España)
funder
Janssen Cilag
funder
Institut National de la Santé et de la Recherche Médicale (Francia)
funder
Wellcome Trust
funder
Gilead Sciences (Spain)
funder
Ministère de la Santé (Francia)
funder
Austrian Agency for Health and Food Safety
funder
Stichting HIV Monitoring
funder
German Center for Infection Research (Alemania)
funder
Ministry of Health Welfare and Sport (Países Bajos)
funder
National Institute for Health Research (Reino Unido)
funder
Agence Nationale de Recherches sur le sida et les hépatites virales (Francia)
funder
ViiV Healthcare
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Alberta Health (Canadá)
funder
Integrated Clinical Systems
2023-06-27T11:44:58Z
2023-06-27T11:44:58Z
2023
J Viral Hepat. 2023 Sep;30(9):775-786.
10.1111/jvh.13863
1365-2893
Journal of viral hepatitis
37338017
http://hdl.handle.net/20.500.12105/16193
Among persons with HIV (PWH), higher alcohol use and having hepatitis C virus (HCV) are separately associated with increased morbidity and mortality. We investigated whether the association between alcohol use and mortality among PWH is modified by HCV. Data were combined from European and North American cohorts of adult PWH who started antiretroviral therapy (ART). Self-reported alcohol use data, collected in diverse ways between cohorts, were converted to grams/day. Eligible PWH started ART during 2001-2017 and were followed from ART initiation for mortality. Interactions between the associations of baseline alcohol use (0, 0.1-20.0, >20.0 g/day) and HCV status were assessed using multivariable Cox models. Of 58,769 PWH, 29,711 (51%), 23,974 (41%) and 5084 (9%) self-reported alcohol use of 0 g/day, 0.1-20.0 g/day, and > 20.0 g/day, respectively, and 4799 (8%) had HCV at baseline. There were 844 deaths in 37,729 person-years and 2755 deaths in 443,121 person-years among those with and without HCV, respectively. Among PWH without HCV, adjusted hazard ratios (aHRs) for mortality were 1.18 (95% CI: 1.08-1.29) for 0.0 g/day and 1.84 (1.62-2.09) for >20.0 g/day compared with 0.1-20.0 g/day. This J-shaped pattern was absent among those with HCV: aHRs were 1.00 (0.86-1.17) for 0.0 g/day and 1.64 (1.33-2.02) for >20.0 g/day compared with 0.1-20.0 g/day (interaction p < .001). Among PWH without HCV, mortality was higher in both non-drinkers and heavy drinkers compared with moderate alcohol drinkers. Among those with HCV, mortality was higher in heavy drinkers but not non-drinkers, potentially due to differing reasons for not drinking (e.g. illness) between those with and without HCV.
eng
HIV
Alcohol
Cause-specific
Cohort
Hepatitis C virus
Mortality
Contribution of alcohol use in HIV/hepatitis C virus co-infection to all-cause and cause-specific mortality: A collaboration of cohort studies
research article
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ContributionAlcoholUseHIV_HepatitisC_2023.pdf
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Supplementary_ContributionAlcoholUseHIV_HepatitisC_2023.pdf
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ContributionAlcoholUseHIV_HepatitisC_2023.pdf.txt
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