2026-06-14T05:06:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/161462024-10-31T11:40:29Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Coderch, Claire
author
Arranz-Herrero, Javier
author
Nistal-Villan, Estanislao
author
de Pascual-Teresa, Beatriz
author
Rius-Rocabert, Sergio
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2023-06-06T12:08:18Z
2023-06-06T12:08:18Z
2023-05-20
Int J Mol Sci. 2023 May 20;24(10):9032.
10.3390/ijms24109032
1422-0067
International journal of molecular sciences
37240378
http://hdl.handle.net/20.500.12105/16146
The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.
eng
IFN
STING
Antiviral response
The Many Ways to Deal with STING
journal article
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URL
https://repisalud.isciii.es/bitstreams/8f7ff3a8-6c7e-4d5f-b878-29b5b8a33a23/download
File
MD5
a93ebd6a033150cc0617329648a59565
6825491
application/pdf
ManyWaysDealSTING_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/1e030753-0b26-4b3e-b025-ec66b20cab10/download
File
MD5
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application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Table S1. Enumeration of the crystal structures of human STING found in PDB up to February 2023.xlsx
URL
https://repisalud.isciii.es/bitstreams/d73caf55-e7fd-45ee-8228-797202a96e5a/download
File
MD5
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154913
text/plain
ManyWaysDealSTING_2023.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/77ea9eb1-fd0f-46b5-9d81-883945314d5c/download
File
MD5
d7868991147971ff2eb15baa9c817d6b
12034
text/plain
Table S1. Enumeration of the crystal structures of human STING found in PDB up to February 2023.xlsx.txt