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oai:repisalud.isciii.es:20.500.12105/161462024-10-31T11:40:29Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Coderch, Claire author Arranz-Herrero, Javier author Nistal-Villan, Estanislao author de Pascual-Teresa, Beatriz author Rius-Rocabert, Sergio author 2023-05-20 The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view. Int J Mol Sci. 2023 May 20;24(10):9032. 10.3390/ijms24109032 1422-0067 International journal of molecular sciences 37240378 http://hdl.handle.net/20.500.12105/16146 IFN STING Antiviral response The Many Ways to Deal with STING