2026-05-21T23:07:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/161352024-11-30T00:27:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Vivas-García, Yurena
author
Efeyan, Alejo
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Comisión Europea
funder
Fundación La Caixa
funder
Amigos CNIO
funder
Fundación Domingo Martínez
2023-06-05T09:46:06Z
2023-06-05T09:46:06Z
2022-09-23
Front Mol Biosci . 2022 ;9:991188.
10.3389/fmolb.2022.991188
2296-889X
Frontiers in molecular biosciences
36213123
http://hdl.handle.net/20.500.12105/16135
The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely different energetic requirements as B cells switch from resting to an activated, highly proliferative state and to plasma or memory cell fates. Thus, B cells execute a multi-step, energetically dynamic process of profound metabolic rewiring from low ATP production to transient and large increments of energy expenditure that depend on high uptake and consumption of glucose and fatty acids. Such metabolic plasticity is under tight transcriptional and post-transcriptional regulation. Alterations in B-cell metabolism driven by genetic mutations or by extrinsic insults impair B-cell functions and differentiation and may underlie the anomalous behavior of pathological B cells. Herein, we review molecular switches that control B-cell metabolism and fuel utilization, as well as the emerging awareness of the impact of dynamic metabolic adaptations of B cells throughout the different phases of the humoral response.
eng
METABOLIC PLASTICITY
B-CELL ACTIVATION
HUMORAL RESPONSE
GLYCOLYSIS
OXPHOS
ANABOLISM
The metabolic plasticity of B cells.
journal article
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ThemetabolicplasticityofBcells_2022.pdf
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ThemetabolicplasticityofBcells_2022.pdf.txt