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oai:repisalud.isciii.es:20.500.12105/161352024-11-30T00:27:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Vivas-García, Yurena author Efeyan, Alejo author 2022-09-23 The humoral response requires rapid growth, biosynthetic capacity, proliferation and differentiation of B cells. These processes involve profound B-cell phenotypic transitions that are coupled to drastic changes in metabolism so as to meet the extremely different energetic requirements as B cells switch from resting to an activated, highly proliferative state and to plasma or memory cell fates. Thus, B cells execute a multi-step, energetically dynamic process of profound metabolic rewiring from low ATP production to transient and large increments of energy expenditure that depend on high uptake and consumption of glucose and fatty acids. Such metabolic plasticity is under tight transcriptional and post-transcriptional regulation. Alterations in B-cell metabolism driven by genetic mutations or by extrinsic insults impair B-cell functions and differentiation and may underlie the anomalous behavior of pathological B cells. Herein, we review molecular switches that control B-cell metabolism and fuel utilization, as well as the emerging awareness of the impact of dynamic metabolic adaptations of B cells throughout the different phases of the humoral response. Front Mol Biosci . 2022 ;9:991188. 10.3389/fmolb.2022.991188 2296-889X Frontiers in molecular biosciences 36213123 http://hdl.handle.net/20.500.12105/16135 METABOLIC PLASTICITY B-CELL ACTIVATION HUMORAL RESPONSE GLYCOLYSIS OXPHOS ANABOLISM The metabolic plasticity of B cells.