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00925njm 22002777a 4500 dc Whittaker, Robert author Economopoulou, Assimoula author Dias, Joana Gomes author Bancroft, Elizabeth author Ramliden, Miriam author Celentano, Lucia Pastore author European Centre for Disease Prevention and Control Country Experts for Invasive Haemophilus influenzae Disease author Perez-Vazquez, Maria author Cano-Portero, Rosa author 2017-03 We describe the epidemiology of invasive Haemophilus influenzae disease during 2007-2014 in 12 European countries and assess overall H. influenzae disease trends by serotype and patient age. Mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% CI 2.3% to 4.3%). The notification rate was highest for patients <1 month of age (23.4 cases/100,000 population). Nontypeable H. influenzae (NTHi) caused 78% of all cases and showed increasing trends among persons <1 month and >20 years of age. Serotype f cases showed an increasing trend among persons >60 years of age. Serotype b cases showed decreasing trends among persons 1-5 months, 1-4 years, and >40 years of age. Sustained success of routine H. influenzae serotype b vaccination is evident. Surveillance systems must adopt a broad focus for invasive H. influenzae disease. Increasing reports of NTHi, particularly among neonates, highlight the potential benefit of a vaccine against NTHi. Emerg Infect Dis. 2017 Mar;23(3):396-404. 10.3201/eid2303.161552 1080-6059 Emerging infectious diseases 28220749 http://hdl.handle.net/20.500.12105/16131 Europe Bacteria Coccobacillus Epidemiology Invasive Haemophilus influenzae disease Invasive disease Invasive pathogen Serotype Surveillance Temporal trends Vaccine Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014