2026-06-15T11:34:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/161112025-05-30T13:38:10Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Gallego, Elisa
author
Arias-Merino, Greta
author
Sanchez-Diaz, German
author
Villaverde-Hueso, Ana
author
Posada De la Paz, Manuel
author
Alonso-Ferreira, Veronica
2023-05-24T07:21:07Z
2023-05-24T07:21:07Z
2023-02-28
Int J Environ Res Public Health. 2023 Feb 28;20(5):4374.
10.3390/ijerph20054374
1660-4601
International journal of environmental research and public health
36901385
http://hdl.handle.net/20.500.12105/16111
Familial Mediterranean Fever (FMF) is a rare, hereditary, auto-inflammatory disease. The aims of this study were to explore the time trend and geographical distribution of hospitalizations in Spain from 2008 to 2015. We identified hospitalizations of FMF from the Spanish Minimum Basic Data Set at hospital discharge, using ICD-9-CM code 277.31. Age-specific and age-adjusted hospitalization rates were calculated. The time trend and the average percentage change were analyzed using Joinpoint regression. Standardized morbidity ratios were calculated and mapped by province. A total of 960 FMF-related hospitalizations (52% men) were identified across the period 2008-2015, with an increase in hospitalizations of 4.9% per year being detected (p < 0.05). The risk of hospitalization was higher than expected for the national total (SMR > 1) in 13 provinces (5 in the Mediterranean area), and lower (SMR < 1) in 14 provinces (3 in the Mediterranean area). There was an increase in hospitalizations of patients with FMF in Spain throughout the study period, with a risk of hospitalization that was higher, though not exclusively so, in provinces along the Mediterranean coast. These findings contribute to the visibility of FMF and provide useful information for health planning. Further research should take into account new population-based information, in order to continue monitoring this disease.
eng
Familial Mediterranean Fever
Health information system
Hospitalizations
Population-based study
Rare disease
Familial Mediterranean Fever in Spain: Time Trend and Spatial Distribution of the Hospitalizations
research article
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FamilialMediterraneanFeverSpain_2023.pdf
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https://repisalud.isciii.es/bitstreams/7e779229-d16c-4a6e-ac3e-73150fb9085d/download
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FamilialMediterraneanFeverSpain_2023.pdf.txt