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oai:repisalud.isciii.es:20.500.12105/161062025-04-23T10:50:40Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Bil, W author Govarts, E author Zeilmaker, M J author Woutersen, M author Bessems, J author Ma, Y author Thomsen, C author Haug, L S author Lignell, S author Gyllenhammar, I author Palkovicova Murinova, Lubica author Fábelová, Lucia author Tratnik, J Snoj author Kosjek, T author Gabriel, C author Sarigiannis, D author Pedraza-Diaz, Susana author Esteban-Lopez, Marta author Castaño, Argelia author Rambaud, L author Riou, M author Franken, C author Colles, A author Vogel, N author Kolossa-Gehring, Marike author Halldórsson, Thórhallur Ingi author Uhl, M author Schoeters, G author Santonen, T author Vinggaard, A M author 2023-01 Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, and bioaccumulative class of chemicals, of which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health and the environment. Within the European Biomonitoring Initiative HBM4EU, samples and data were collected in a harmonized way from human biomonitoring (HBM) studies in Europe to derive current exposure data across a geographic spread. We performed mixture risk assessments based on recent internal exposure data of PFASs in European teenagers generated in the HBM4EU Aligned Studies (dataset with N = 1957, sampling years 2014-2021). Mixture risk assessments were performed based on three hazard-based approaches: the Hazard Index (HI) approach, the sum value approach as used by the European Food Safety Authority (EFSA) and the Relative Potency Factor (RPF) approach. The HI approach resulted in the highest risk estimates, followed by the RPF approach and the sum value approach. The assessments indicate that PFAS exposure may result in a health risk in a considerable fraction of individuals in the HBM4EU teenager study sample, thereby confirming the conclusion drawn in the recent EFSA scientific opinion. This study underlines that HBM data are of added value in assessing the health risks of aggregate and cumulative exposure to PFASs, as such data are able to reflect exposure from different sources and via different routes. Int J Hyg Environ Health. 2023 Jan;247:114071. http://hdl.handle.net/20.500.12105/16106 36446273 10.1016/j.ijheh.2022.114071 1618-131X International journal of hygiene and environmental health Blood concentration HBM4EU Mixture PFAS Risk assessment Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data