2026-04-29T13:12:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/161042025-05-12T09:39:46Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Buekers, Jurgen author Baken, Kirsten author Govarts, Eva author Rodriguez Martin, Laura author Vogel, Nina author Kolossa-Gehring, Marike author Šlejkovec, Zdenka author Falnoga, Ingrid author Horvat, Milena author Lignell, Sanna author Lindroos, Anna Karin author Rambaud, Loïc author Riou, Margaux author Pedraza-Diaz, Susana author Esteban-Lopez, Marta author Castaño, Argelia author Den Hond, Elly author Baeyens, Willy author Santonen, Tiina author Schoeters, Greet author 2023-03 The European Joint Programme HBM4EU coordinated and advanced human biomonitoring (HBM) in Europe in order to provide science-based evidence for chemical policy development and improve chemical management. Arsenic (As) was selected as a priority substance under the HBM4EU initiative for which open, policy relevant questions like the status of exposure had to be answered. Internal exposure to inorganic arsenic (iAs), measured as Toxic Relevant Arsenic (TRA) (the sum of As(III), As(V), MMA, DMA) in urine samples of teenagers differed among the sampling sites (BEA (Spain) > Riksmaten adolescents (Sweden), ESTEBAN (France) > FLEHS IV (Belgium), SLO CRP (Slovenia)) with geometric means between 3.84 and 8.47 μg/L. The ratio TRA to TRA + arsenobetaine or the ratio TRA to total arsenic varied between 0.22 and 0.49. Main exposure determinants for TRA were the consumption of rice and seafood. When all studies were combined, Pearson correlation analysis showed significant associations between all considered As species. Higher concentrations of DMA, quantitatively a major constituent of TRA, were found with increasing arsenobetaine concentrations, a marker for organic As intake, e.g. through seafood, indicating that other sources of DMA than metabolism of inorganic As exist, e.g. direct intake of DMA or via the intake of arsenosugars or -lipids. Given the lower toxicity of DMA(V) versus iAs, estimating the amount of DMA not originating from iAs, or normalizing TRA for arsenobetaine intake could be useful for estimating iAs exposure and risk. Comparing urinary TRA concentrations with formerly derived biomonitoring equivalent (BE) for non-carcinogenic effects (6.4 μg/L) clearly shows that all 95th percentile exposure values in the different studies exceeded this BE. This together with the fact that cancer risk may not be excluded even at lower iAs levels, suggests a possible health concern for the general population of Europe. Int J Hyg Environ Health. 2023 Mar;248:114115. 10.1016/j.ijheh.2023.114115 1618-131X International journal of hygiene and environmental health 36689783 http://hdl.handle.net/20.500.12105/16104 Arsenic DMA EU Exposure HBM HBM4EU TRA Human urinary arsenic species, associated exposure determinants and potential health risks assessed in the HBM4EU Aligned Studies