2026-07-22T03:36:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/160842025-04-03T18:27:20Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16964col_20.500.12105_16977
Repisalud
author
Gonzalez-Perez, Maria
author
Baranda Prellezo, Jana
author
Berges-Buxeda, Marcos Joaquín
author
Conde-San Román, Patricia
author
Perez-Olmeda, Mayte
author
Lozano-Ojalvo, Daniel
author
Cámara, Carmen
author
Llópez-Carratalá, Maria del Rosario
author
Gonzalez-Parra, Emilio
author
Portoles, Pilar
author
Ortiz, Alberto
author
Portoles, Jose
author
Ochando, Jordi
funder
Instituto de Salud Carlos III
funder
Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. H2020
2023-05-17T12:17:29Z
2023-05-17T12:17:29Z
2023-04-11
Pharmaceuticals (Basel). 2023 Apr 11;16(4):574.
10.3390/ph16040574
1424-8247
Pharmaceuticals (Basel, Switzerland)
37111331
http://hdl.handle.net/20.500.12105/16084
Continuous evaluation of the coronavirus disease 2019 (COVID-19) vaccine effectiveness in hemodialysis (HD) patients is critical in this immunocompromised patient group with higher mortality rates due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The response towards vaccination in HD patients has been studied weeks after their first and second SARS-CoV-2 vaccination dose administration, but no further studies have been developed in a long-term manner, especially including both the humoral and cellular immune response. Longitudinal studies that monitor the immune response to COVID-19 vaccination in individuals undergoing HD are therefore necessary to prioritize vaccination strategies and minimize the pathogenic effects of SARS-CoV-2 in this high-risk group of patients. We followed up HD patients and healthy volunteers (HV) and monitored their humoral and cellular immune response three months after the second (V2+3M) and after the third vaccination dose (V3+3M), taking into consideration previous COVID-19 infections. Our cellular immunity results show that, while HD patients and HV individuals secrete comparable levels of IFN-γ and IL-2 in ex vivo stimulated whole blood at V2+3M in both naïve and COVID-19-recovered individuals, HD patients secrete higher levels of IFN-γ and IL-2 than HV at V3+3M. This is mainly due to a decay in the cellular immune response in HV individuals after the third dose. In contrast, our humoral immunity results show similar IgG binding antibody units (BAU) between HD patients and HV individuals at V3+3M, independently of their previous infection status. Overall, our results indicate that HD patients maintain strong cellular and humoral immune responses after repeated 1273-mRNA SARS-CoV-2 vaccinations over time. The data also highlights significant differences between cellular and humoral immunity after SARS-CoV-2 vaccination, which emphasizes the importance of monitoring both arms of the immune response in the immunocompromised population.
eng
1273-mRNA vaccine
COVID-19
SARS-CoV-2 vaccine
Cellular response
Chronic kidney disease
Hemodialysis
Humoral response
Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
research article
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MaintenancePotentCellularHumoral_2023.pdf
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MaintenancePotentCellularHumoral_2023.pdf.txt