2026-08-29T14:17:54Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/160662025-05-08T07:48:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974

00925njm 22002777a 4500 dc Orive, Miren author Barrio, Irantzu author Lázaro, Santiago author González, Nerea author Baré, Marisa author Fernandez de Larrea-Baz, Nerea author Redondo, Maximino author Cortajarena, Sarai author Bilbao, Amaia author Aguirre, Urko author Sarasqueta, Cristina author Quintana, Jose Maria author REDISSEC-CARESS/CCR group author 2023-03-09 Purpose: To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient's health-related quality of life (HRQoL) status. Methods: Prospective observational cohort study of CRC patients. We collected data from their diagnosis, intervention, and at 1, 2, 3, and 5 years following the index intervention, also collecting HRQoL data using the EuroQol-5D-5L (EQ-5D-5L), European Organization for Research and Treatment of Cancer's Quality of Life Questionnaire-Core 30 (EORTC-QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Multivariate Cox proportional models were used. Results: We found predictors of mortality over the 5-year follow-up to be being older; being male; having a higher TNM stage; having a higher lymph node ratio; having a result of CRC surgery classified as R1 or R2; invasion of neighboring organs; having a higher score on the Charlson comorbidity index; having an ASA IV; and having worse scores, worse quality of life, on the EORTC and EQ-5D questionnaires, as compared to those with higher scores in each of those questionnaires respectively. Conclusions: These results allow preventive and controlling measures to be established on long-term follow-up of these patients, based on a few easily measurable variables. Implications for cancer survivors: Patients with colorectal cancer should be monitored more closely depending on the severity of their disease and comorbidities as well as the perceived health-related quality of life, and preventive measures should be established to prevent adverse outcomes and therefore to ensure that better treatment is received. Trial registration: ClinicalTrials.gov identifier: NCT02488161. Int J Colorectal Dis. 2023 Mar 9;38(1):64. 10.1007/s00384-023-04358-0 1432-1262 International journal of colorectal disease 36892600 http://hdl.handle.net/20.500.12105/16066 Cohort studies Colorectal cancer Health-related quality of life Patient-reported outcome measures Survival models Five-year follow-up mortality prognostic index for colorectal patients