2026-06-14T03:44:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/160642025-04-24T17:55:56Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16959col_20.500.12105_16973col_20.500.12105_16974col_20.500.12105_16978col_20.500.12105_16988col_20.500.12105_25179
Repisalud
author
Vázquez-Morón, Sonia
author
Iglesias-Caballero, Maria
author
Lepe, José Antonio
author
García, Federico
author
Melón, Santiago
author
Marimón, José María
author
García de Viedma, Darío
author
Folgueira, María Dolores
author
Galán, Juan Carlos
author
López-Causapé, Carla
author
Benito-Ruesca, Rafael
author
Alcoba-Florez, Julia
author
Gonzalez Candelas, Fernando
author
de Toro, María
author
Fajardo, Miguel
author
Ezpeleta, Carmen
author
Lázaro, Fernando
author
Pérez Castro, Sonia
author
Cuesta de la Plaza, Isabel
author
Zaballos, Ángel
author
Pozo Sanchez, Francisco
author
Casas Flecha, Inmaculada
author
RELECOV Network Members
funder
Unión Europea. European Centre for Disease Prevention and Control (ECDC)
funder
Instituto de Salud Carlos III
funder
Gobierno de Canarias (España)
funder
Fundación Canaria de Investigación Sanitaria
funder
Unión Española de Entidades Aseguradoras y Reaseguradoras
2023-05-16T13:05:16Z
2023-05-16T13:05:16Z
2023-05
Int. J. Mol. Sci. 2023, 24(10), 8573.
10.3390/ijms24108573
1422-0067
International Journal of Molecular Sciences
http://hdl.handle.net/20.500.12105/16064
Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network’s technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain.
eng
SARS-CoV-2
Genomic surveillance Spain
Laboratory network RELECOV
VOCs
Lineages
National QCA
Mutation
Phylogeny
Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network
research article
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