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00925njm 22002777a 4500 dc Vázquez-Morón, Sonia author Iglesias-Caballero, Maria author Lepe, José Antonio author García, Federico author Melón, Santiago author Marimón, José María author García de Viedma, Darío author Folgueira, María Dolores author Galán, Juan Carlos author López-Causapé, Carla author Benito-Ruesca, Rafael author Alcoba-Florez, Julia author Gonzalez Candelas, Fernando author de Toro, María author Fajardo, Miguel author Ezpeleta, Carmen author Lázaro, Fernando author Pérez Castro, Sonia author Cuesta de la Plaza, Isabel author Zaballos, Ángel author Pozo Sanchez, Francisco author Casas Flecha, Inmaculada author RELECOV Network Members author 2023-05 Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network’s technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain. Int. J. Mol. Sci. 2023, 24(10), 8573. 10.3390/ijms24108573 1422-0067 International Journal of Molecular Sciences http://hdl.handle.net/20.500.12105/16064 SARS-CoV-2 Genomic surveillance Spain Laboratory network RELECOV VOCs Lineages National QCA Mutation Phylogeny Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network