2026-04-29T19:34:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/160382025-05-27T11:19:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Juste, Ramón A
author
Ferreras-Colino, Elisa
author
de la Fuente, José
author
Dominguez-Rodriguez, Mercedes
author
Risalde, María A
author
Domínguez, Lucas
author
Cabezas-Cruz, Alejandro
author
Gortázar, Christian
funder
Regional Government of Castile-La Mancha (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Gobierno del Principado de Asturias (España)
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
2023-05-09T13:44:58Z
2023-05-09T13:44:58Z
2022-10
Immunology. 2022 Oct;167(2):139-153.
10.1111/imm.13529
1365-2567
Immunology
35752944
http://hdl.handle.net/20.500.12105/16038
Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that enhances their primary defensive capabilities. Cross-pathogen protective TRAIM can be triggered in different hosts by exposure to live microbes or microbe-derived products such as heat-inactivated Mycobacterium bovis or with the glycan α-Gal to elicit protective responses against several pathogens. We review the TRAIM paradigm using two models representing distinct scales of immune sensitization: the whole bacterial cell and one of its building blocks, the polysaccharides or glycans. Observations point out to macrophage lytic capabilities and cytokine regulation as two key components in non-specific innate immune responses against infections. The study of the TRAIM response deserves attention to better characterize the evolution of host-pathogen cooperation both for identifying the aetiology of some diseases and for finding new therapeutic strategies. In this field, the zebrafish provides a convenient and complete biological system that could help to deepen in the knowledge of TRAIM-mediated mechanisms in pathogen-host interactions.
eng
Cross-protection
Glycan alpha-Gal
Heat-inactivated Mycobacterium bovis
Macrophages
Trained innate immunity
Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model
research article
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URL
https://repisalud.isciii.es/bitstreams/69e96bf2-349f-42de-8d0e-dc3f3a62df38/download
File
MD5
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application/pdf
HeatInactivatedMycobacteriaAlpha_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/e88af930-1d4a-43e3-94f0-e866e8e30a53/download
File
MD5
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text/plain
HeatInactivatedMycobacteriaAlpha_2022.pdf.txt