2026-04-29T19:34:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/160382025-05-27T11:19:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Juste, Ramón A author Ferreras-Colino, Elisa author de la Fuente, José author Dominguez-Rodriguez, Mercedes author Risalde, María A author Domínguez, Lucas author Cabezas-Cruz, Alejandro author Gortázar, Christian author 2022-10 Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that enhances their primary defensive capabilities. Cross-pathogen protective TRAIM can be triggered in different hosts by exposure to live microbes or microbe-derived products such as heat-inactivated Mycobacterium bovis or with the glycan α-Gal to elicit protective responses against several pathogens. We review the TRAIM paradigm using two models representing distinct scales of immune sensitization: the whole bacterial cell and one of its building blocks, the polysaccharides or glycans. Observations point out to macrophage lytic capabilities and cytokine regulation as two key components in non-specific innate immune responses against infections. The study of the TRAIM response deserves attention to better characterize the evolution of host-pathogen cooperation both for identifying the aetiology of some diseases and for finding new therapeutic strategies. In this field, the zebrafish provides a convenient and complete biological system that could help to deepen in the knowledge of TRAIM-mediated mechanisms in pathogen-host interactions. Immunology. 2022 Oct;167(2):139-153. 10.1111/imm.13529 1365-2567 Immunology 35752944 http://hdl.handle.net/20.500.12105/16038 Cross-protection Glycan alpha-Gal Heat-inactivated Mycobacterium bovis Macrophages Trained innate immunity Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model