2026-06-14T03:53:29Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/160222025-05-08T06:44:04Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Mir-Cros, Alba
author
Moreno-Mingorance, Albert
author
Martín-Gómez, María Teresa
author
Abad, Raquel
author
Bloise, Iván
author
Campins, Magda
author
González-Praetorius, Alejandro
author
Gutiérrez, M Nieves
author
Martín-González, Héctor
author
Muñoz-Almagro, Carmen
author
Orellana, M Ángeles
author
de Pablos, Manuela
author
Roca-Grande, Josep
author
Rodrigo, Carlos
author
Rodríguez, M Elena
author
Uriona, Sonia
author
Vidal, M José
author
Pumarola, Tomas
author
Larrosa, M Nieves
author
González-López, Juan José
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
Agència de Gestió d´Ajuts Universitaris i de Recerca (AGAUR)
funder
Vall d´Hebron Institut de Recerca
2023-05-09T07:33:07Z
2023-05-09T07:33:07Z
2022-05
Emerg Infect Dis. 2022 May;28(5):967-976.
10.3201/eid2805.211958
1080-6059
Emerging infectious diseases
35447067
http://hdl.handle.net/20.500.12105/16022
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(-292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV.
eng
Bordetella pertussis
Spain
Bacteria
Pertussis vaccine
Phylogenetic evolution
Virulence factors
Whooping cough
Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018
research article
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Pertactin-DeficientBordetellaPertussis_2022.pdf
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Pertactin-DeficientBordetellaPertussis_2022.pdf.txt
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