2026-07-23T23:01:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/160142024-11-30T00:12:55Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Barradas, Marta
author
Plaza, Adrián
author
Colmenarejo, Gonzalo
author
Lázaro, Iolanda
author
Costa-Machado, Luis Filipe
author
Martín-Hernández, Roberto
author
Micó, Victor
author
López-Aceituno, José Luis
author
Herranz, Jesús
author
Tejero, Hector
author
Diaz-Ruiz, Alberto
author
Daimiel, Lidia
author
Loria-Kohen, Viviana
author
Ramirez de Molina, Ana
author
Serrano, Manuel
author
Pozo, Oscar J
author
Sala-Vila, Aleix
author
Fernandez-Marcos, Pablo J
author
Al-Shahrour, Fatima
author
Pantoja, Cristina
author
Efeyan, Alejo
funder
Fundación Ramón Areces
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2023-05-08T12:11:53Z
2023-05-08T12:11:53Z
2022-09-27
Nat Commun. 2022 ;13(1):5677.
10.1038/s41467-022-33352-3
2041-1723
Nature communications
36167809
http://hdl.handle.net/20.500.12105/16014
Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.
eng
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.
journal article
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