2026-07-23T23:01:35Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/160142024-11-30T00:12:55Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Barradas, Marta author Plaza, Adrián author Colmenarejo, Gonzalo author Lázaro, Iolanda author Costa-Machado, Luis Filipe author Martín-Hernández, Roberto author Micó, Victor author López-Aceituno, José Luis author Herranz, Jesús author Tejero, Hector author Diaz-Ruiz, Alberto author Daimiel, Lidia author Loria-Kohen, Viviana author Ramirez de Molina, Ana author Serrano, Manuel author Pozo, Oscar J author Sala-Vila, Aleix author Fernandez-Marcos, Pablo J author Al-Shahrour, Fatima author Pantoja, Cristina author Efeyan, Alejo author 2022-09-27 Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity. Nat Commun. 2022 ;13(1):5677. 10.1038/s41467-022-33352-3 2041-1723 Nature communications 36167809 http://hdl.handle.net/20.500.12105/16014 Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.