2026-07-21T16:29:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159822025-05-08T10:44:07Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978
Repisalud
author
Gil-Manso, Sergio
author
Carbonell, Diego
author
Pérez-Fernández, Verónica Astrid
author
López-Esteban, Rocío
author
Alonso, Roberto
author
Muñoz, Patricia
author
Ochando, Jordi
author
Sanchez-Arcilla, Ignacio
author
Bellón, José María
author
Correa-Rocha, Rafael
author
Pion, Marjorie
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación Familia Alonso
2023-05-05T09:25:37Z
2023-05-05T09:25:37Z
2022-07-12
Biomedicines. 2022 Jul 12;10(7):1676.
10.3390/biomedicines10071676
2227-9059
Biomedicines
35884980
http://hdl.handle.net/20.500.12105/15982
Vaccination against SARS-CoV-2 has become the main method of reducing mortality and severity of COVID-19. This work aims to study the evolution of the cellular and humoral responses conferred by two mRNA vaccines after two doses against SARS-CoV-2. On days 30 and 240 after the second dose of both vaccines, the anti-S antibodies in plasma were evaluated from 82 volunteers vaccinated with BNT162b2 and 68 vaccinated with mRNA-1273. Peripheral blood was stimulated with peptides encompassing the entire SARS-CoV-2 Spike sequence. IgG Anti-S antibodies (humoral) were quantified on plasma, and inflammatory cytokines (cellular) were measured after stimulation. We observed a higher response (both humoral and cellular) with the mRNA-1273 vaccine. Stratifying by age and gender, differences between vaccines were observed, especially in women under 48 and men over 48 years old. Therefore, this work could help to set up a vaccination strategy that could be applied to confer maximum immunity.
eng
COVID-19
SARS-CoV-2
Cellular responses
Humoral responses
mRNA-vaccines
Cellular and Humoral Responses Follow-up for 8 Months after Vaccination with mRNA-Based Anti-SARS-CoV-2 Vaccines
research article
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URL
https://repisalud.isciii.es/bitstreams/65fb05b0-9d4e-4041-ab7b-06a07436c584/download
File
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application/pdf
CellularHumoralResponsesFollow-up_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/9647cddd-af62-43c5-b042-6c407024f0f3/download
File
MD5
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text/plain
CellularHumoralResponsesFollow-up_2022.pdf.txt