2026-07-21T14:15:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159512025-06-19T07:29:45Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19613
Repisalud
author
Fongwen, Noah
author
Asiedu, Kingsley B
author
Bakhiet, Sahar
author
Bonifaz, Alexandro
author
Cruz, Israel
author
Argaw, Daniel
author
Estrada-Chavez, Guadalupe
author
Fahal, Ahmed H
author
Litvintseva, Ana
author
Marks, Michael
author
Salinas-Carmona, Mario C
author
Sow, Doudou
author
van de Sande, Wendy W J
2023-05-04T07:32:46Z
2023-05-04T07:32:46Z
2022-12
Trop Med Int Health. 2022 Dec;27(12):1059-1064.
10.1111/tmi.13828
1365-3156
Tropical medicine & international health : TM & IH
36329624
http://hdl.handle.net/20.500.12105/15951
Objective: Mycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high-priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed. Methods: We describe the development of two TPPs: one for a diagnostic test able to identify the causative agent of mycetoma and another that would determine when treatment could be stopped. The TPPs were developed by considering product use, design, performance, product configuration and costs. Results: Version 1.0 TPPs for two uses were posted by WHO for a 1-month online public consultation on 25 October 2021, and the final TPP was posted online on 5 May 2022. Conclusion: A major difficulty encountered in developing both TPPs was the large number of agents able to cause mycetoma and the lack of specific biomarkers for most of them.
eng
Actinomycetoma
Eumycetoma
Mycetoma
Point-of-care test
Target product profile
WHO
Diagnostics to support mycetoma management-Development of two target product profiles
research article
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URL
https://repisalud.isciii.es/bitstreams/c78e1d3d-33fd-4b9e-b6da-b88755614c87/download
File
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DiagnosticsSupportMycetomaManagement_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/ca767422-0185-4af6-8aea-7f296b5ed453/download
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DiagnosticsSupportMycetomaManagement_2022.pdf.txt