2026-04-17T03:10:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159422025-06-19T13:25:39Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19613col_20.500.12105_16982
Repisalud
author
GBD 2019 Cancer Risk Factors Collaborators
author
Padron-Monedero, Alicia
funder
Bill & Melinda Gates Foundation
funder
Ministry of Higher Education (Malasia)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea. H2020
funder
Fundação para a Ciência e Tecnologia (Portugal)
funder
Federal Ministry of Education & Research (Alemania)
funder
Alexander von Humboldt Foundation
funder
Novo Nordisk Foundation
funder
National Institute for Health Research (Reino Unido)
funder
National Health and Medical Research Council (Australia)
funder
Ministry of Education, Science and Technological Development (Serbia)
funder
Sigrid Jusélius Foundation
funder
National Natural Science Foundation of China
funder
Wellcome Trust
funder
National Council for Scientific and Technological Development (Brasil)
funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)
funder
National Institutes of Health (Estados Unidos)
funder
University of Oxford (Reino Unido)
funder
Ministero della Salute (Italia)
funder
King College London
funder
DBT India Alliance (India)
funder
Kuwait University (Kuwait)
funder
Lega Italiana per la Lotta ai Tumori
funder
Health Effects Institute (Estados Unidos)
funder
African-German Network of Excellence in Science (AGNES)
funder
Romanian National Authority for Scientific Research and Innovation
funder
Romanian Ministry of Research Innovation and Digitalization
funder
Finnish Cancer Foundation
funder
Datta Meghe Institute of Medical Sciences (India)
funder
Xiamen University Malaysia (Malasia)
funder
Manipal Academy of Higher Education (India)
funder
Panjab University (India)
funder
Sistema Nacional de Investigación (Panamá)
funder
Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá)
funder
Ministry of Science and Technology (Taiwan)
funder
Lung Foundation Australia
funder
UNSW Sydney (Australia)
funder
ICMR - National Institute of Epidemiology (India)
funder
University of Tasmania (Australia)
funder
Institute for Advanced Studies in Basic Sciences (Irán)
funder
Ain Shams University (Egipto)
funder
International Center of Medical Sciences Research (Islamabad)
funder
National Institute of Genetic Engineering and Biotechnology (Irán)
funder
Marga und Walter Boll - Stiftung
funder
IRCCS Materno Infantile Burlo Garofolo (Italia)
2023-05-03T09:56:31Z
2023-05-03T09:56:31Z
2022-08-20
Lancet. 2022 Aug 20;400(10352):563-591.
http://hdl.handle.net/20.500.12105/15942
35988567
10.1016/S0140-6736(22)01438-6
1474-547X
Lancet (London, England)
Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]). Interpretation: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.
eng
The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
research article
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GlobalBurdenCancerAttributable_2022.pdf
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GlobalBurdenCancerAttributable_2022.pdf.txt