2026-05-04T09:25:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/159372025-06-19T15:57:58Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19613col_20.500.12105_16982
Repisalud
author
GBD 2020 Alcohol Collaborators
author
Padron-Monedero, Alicia
funder
Bill & Melinda Gates Foundation
funder
Alexander von Humboldt Foundation
funder
University of Oxford (Reino Unido)
funder
Medical Research Council (Reino Unido)
funder
NIH - National Institute of Mental Health (NIMH) (Estados Unidos)
funder
Canada Research Chairs
funder
National Health and Medical Research Council (Australia)
funder
Ministry of Education, Science and Technological Development (Serbia)
funder
Wellcome Trust
funder
NIH - National Institute on Aging (NIA) (Estados Unidos)
funder
Finlands Akademi (Finlandia)
funder
Federal Ministry of Education & Research (Alemania)
funder
National Council for Scientific and Technological Development (Brasil)
funder
Danish National Research Foundation
funder
National Natural Science Foundation of China
funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)
funder
Ministerio de Ciencia e Innovación (España)
funder
King Edward Medical University (Pakistán)
funder
National Heart Foundation of Australia
funder
Panjab University (India)
funder
Queensland Centre for Mental Health Research (Australia)
funder
South African Medical Research Council
funder
Charles Sturt University (Australia)
funder
Ain Shams University (Egipto)
funder
Mizoram University (India)
funder
Kasturba Medical College (India)
funder
Manipal Academy of Higher Education (India)
2023-05-03T08:37:39Z
2023-05-03T08:37:39Z
2022-07-16
Lancet. 2022 Jul 16;400(10347):185-235.
10.1016/S0140-6736(22)00847-9
1474-547X
Lancet (London, England)
35843246
http://hdl.handle.net/20.500.12105/15937
Background: The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods: For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 15-95 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol. Findings: The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 15-39 years in 2020, the TMREL varied between 0 (95% uncertainty interval 0-0) and 0·603 (0·400-1·00) standard drinks per day, and the NDE varied between 0·002 (0-0) and 1·75 (0·698-4·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (0-0·403) to 1·87 (0·500-3·30) standard drinks per day and an NDE that ranged between 0·193 (0-0·900) and 6·94 (3·40-8·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·3-65·4) were aged 15-39 years and 76·9% (73·0-81·3) were male. Interpretation: There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
eng
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
research article
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URL
https://repisalud.isciii.es/bitstreams/acbacaea-b2b2-4581-84c5-8f746c7b1903/download
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application/pdf
Population-levelRisksAlcoholConsumption_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/9b538421-3fd1-4738-8735-a20967ec0c6b/download
File
MD5
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text/plain
Population-levelRisksAlcoholConsumption_2022.pdf.txt